Sozu
Sozu is a boss relic that grants 1 additional Energy at the start of each turn while preventing the player from obtaining any Potions for the remainder of the run. It is offered as a boss relic reward after defeating an Act boss and represents a direct trade of the potion system for a permanent Energy upgrade.
The extra Energy is one of the most powerful effects in the game, enabling additional card plays every turn, and many strong runs can afford to give up potions entirely. Potions are particularly valuable as emergency tools — saving you from lethal damage, removing a debuff, or enabling a key kill — so Sozu is weakest when your deck has low consistency and relies on potions as a safety net. It is strongest on powerful, consistent decks that rarely need potion bailouts, especially if you haven't found many useful potions by the time you pick it up. Sozu pairs well with strategies that generate so much throughput that individual fights rarely become desperate. Be cautious if you've already built around specific potions or if your build is fragile through the mid and late Acts.