Vampires

Vampires is an Act 2 event where a group of vampires makes an offer: accept to have all Strike cards removed from your deck and receive 5 Bite cards in their place, but lose 30% of your maximum HP. Bite is a 1-cost Attack that deals 7 damage and heals you for 2 HP when played. The 5 Bites replace all copies of Strike (including upgraded Strikes) in your deck.

Vampires is a particularly powerful event for The Ironclad, whose Strength scaling makes Bite's damage and healing synergize excellently with a high-Strength deck. For other characters, the value depends on how many Strikes they still have — if deck-thinning has already removed most Strikes, accepting gives fewer Bites but costs the same 30% HP. The healing from Bite is meaningful in long fights and can help sustain HP across a run. Generally, accepting is correct if you have 3+ Strikes remaining and your run can afford the max HP loss.