Omamori

Omamori is a common relic that blocks the next 2 Curses you would obtain, preventing them from being added to your deck entirely. Curses can come from events, certain boss relics (like Cursed Key or Calling Bell), and other sources. Two charges are shown on the relic, and each blocked Curse consumes one charge.

The relic's value depends heavily on how many Cursed scenarios you encounter. In a run where you pick up Cursed Key or Calling Bell (both of which inflict Curses), Omamori can negate several deck-polluting cards. It is also useful when you want to take events that might curse you without facing the penalty. Once both charges are used, the relic provides no further benefit. Omamori can be intentionally synergistic with Darkstone Periapt (which gives Max HP when you get a Curse) — you use the Periapt to gain HP from forced Curses before switching to blocking them with Omamori.